Professor Siddharthan Chandran is Director of CCBS. His work spans clinical and laboratory activity in the area of Regenerative Neurology.
Neurodegenerative diseases affect cells in the nervous system called neurons. Twenty million people worldwide are diagnosed with a neurodegenerative disease each year, and at present they are all progressive and incurable.
The Chandran group links clinical activity with laboratory research into two such conditions: multiple sclerosis and motor neurone disease. Measuring disease course and treatment outcomes through disease bio-registers builds an increasingly accurate clinical picture.
In parallel, studies in the lab —including using human stem cells—focus on understanding what is going wrong in the neurons and supporting cells called glia. Bringing these two strands together, the group aims to develop novel regenerative therapies and bring them to early-phase clinical trials.
Professor Siddharthan Chandran works in the emerging discipline of Regenerative Neurology. His research combines laboratory activity that includes human stem cells with specialist clinics (multiple sclerosis [MS] and motor neurone disease [MND]) to both study disease as well as undertake early-phase clinical trials.
The ultimate aim is to develop novel regenerative therapies for neurodegenerative disease.
Clinical research, based at the Anne Rowling Regenerative Neurology Clinic, is founded on specialist clinics and linked disease registries to develop a clinical experimental infrastructure for longitudinal studies.
Current collaborative clinical projects include:
Lab research is focused on the glial-neuronal interaction in health and disease.
Current approaches include:
At the University of Edinburgh, Siddharthan Chandran is Director of the Centre for Clinical Brain Sciences; Director of two philanthropically funded centres: the Euan MacDonald Centre for Motor Neurone Disease Research and Anne Rowling Regenerative Neurology Clinic; and a Principal Investigator of the MRC Centre for Regenerative Medicine and the Centre for Neuroregeneration.
Prof Chandran is also Associate Director of the Centre for Brain Development and Repair (CBDR), a large-scale India-UK research collaboration.
The Euan MacDonald Centre is a “centre without walls” of 35 researchers across Scotland that seeks to improve the lives of patients living with MND through fundamental discovery research as well as a growing portfolio of patient-centred research projects.
The Anne Rowling Clinic is a clinical research facility focusing on a wide range of neurological conditions, especially neurodegenerative diseases.