Edinburgh Reproductive Tissue Biobank

Studies

Studies currently utilising the Edinburgh Reproductive Tissue Bio Bank’s Resources.

Project Title and Bio Bank Code

Developing a method of cervical epithelial culture
ERTBB-001
 
Hormone Profiles in Twin Pregnancies
ERTBB-002
 
Study of Cortisol in Overweight Pregnancy (SCOOP)
ERTBB-003
 

Hormone, metabolite and vitamin profiles during pregnancy

ERTBB-011
 

Epigenetic modifications in the early life programming of disease:  impact of maternal nutritional status

ERTBB-013
 
Infection and inflammation in fetal membranes
ERTBB-015
 
Identification and characterisation of novel therapeutic targets for angiogenesis-based disorders of pregnancy – (HUVECs)
ERTBB-024
 
Identify and characterise novel therapeutic targets for angiogenesis-based disorders of pregnancy – identifying biomarkers in biological fluids
ERTBB-026

 

Identify and characterise novel therapeutic targets for angiogenesis-based disorders of pregnancy – tissue biomarkers
ERTBB-027

 

Novel mediators of inflammatory pathways in labour – downstream targets of PGF2α
ERTBB-029
 
Pilot study to test methods of performing chorionic villus sampling (CVS)
ERTBB-030
 
Cervicovaginal secretion markers of labour
ERTBB-031

 

Is there an ‘ageing’ process in the placenta and uterus involved in timing labour?
ERTBB-032

 

Characterising ‘transcription factories’ in the placenta and uterus during pregnancy and labour
ERTBB-033

 

Prematurity and programming: search for stable biomarkers of risk
ERTBB-037

 

Podocyte repair and recovery in kidney disease
ERTBB-038

 

Anti-inflammatory mediators in the female reproductive tract
ERTBB-040

 

Vitamin D and  Antimicrobial Protein Production
ERTBB-041

 

Comparison of 5 hydroxymethylation status in the placenta between small for gestational age, appropriate for gestational age and large for gestational age infants
ERTBB-042

 

Effect of pregnancy in obese subject – mass spectrometry control carrier plasma sample
ERTBB-043

 

Role of complement in myometrial contractility
ERTBB-044
 
In vitro method for predicting skin sensitisation potential of compounds, using dendritic-like cells derived from human cord blood and placenta (Pilot / preliminary feasibility and test exploratory study for commercial test with Charles River)
ERTBB-045
 
Defining the origin of endothelial progenitor cells
ERTBB-046

 

Metabolic processes in obese pregnant women
ERTBB-047
 
Prolactin levels in severely obese pregnancy: a pilot study
ERTBB-048

 

Identify and characterise novel therapeutic targets for angiogenesis-based disorders of pregnancy – MicroRNAs as potential biomarkers
ERTBB-049

 

Unexpected protection from visceral fat expansion from diet induced obesity
ERTBB-050
 
Role of estrogen and estrogen receptors in parturition
ERTBB-051

 

Regulation of 11betahydroxysteroid dehydrogenase expression and activity in term placenta
ERTBB-052

 

Expression and regulation of estrogen receptors and estrogen related receptors in placenta, membranes and uterus.
ERTBB-053

 

What are the epigenetic effects of in utero exposure to maternal diabetes?
ERTBB-054

 

Development of a non-invasive strategy enhancing haematopoietic stem cell potential of human umbilical cord cells
ERTBB-055

 

Histology – small research facility (SRF) (for controls)
ERTBB-056
 
Coupling infection to myometrial contraction
ERTBB-057

 

Identify and characterise novel therapeutic targets for pregnancy related abnormal angiogenesis in diabetes
ERTBB-059

 

Detection of fetal nucleic acids from maternal serum extracted using a microfluidic lab-on-a-chip device
ERTBB-060

 

The impact of estrogen receptor signalling in neuroangiogenesis during endometriosis
ERTBB-061

 

Antimicrobials in non-pregnant cervico-vaginal secretions
ERTBB-062
 
Can 1H MRS and MRI at 3 Tesla detect intrauterine hypoxia in pregnancies with uteroplacental insufficiency?
ERTBB-063

 

Methylation patterns in cord blood
ERTBB-065

 

Gene expression in labouring and non-labouring myometrium
ERTBB-066

 

Imagin’: investigating associations between mother’s wellbeing in pregnancy and fetal brain size
ERTBB-067

 

CHARM – Chlamydia trachomatis and miscarriage
ERTBB-068

 

Investigating the effects of obesity in pregnancy on bone turnover
ERTBB-069

 

Studies of the effect of obesity and gestational diabetes on T-helper cell subsets in pregnant women and their offspring
ERTBB-070

 

The role of heterodimerisation between VEGFR-1 and VEGFR-2 in the regulation of vasculogenesis, angiogenesis and endothelial cell homeostasis
ERTBB-071

 

Improving the clinical utility of umbilical cord blood donations by ex-vivo expansion using mesenchymal stromal cells
ERTBB-072

 

Characterization of urocortins and corticotrophin releasing hormone in placenta and myometrium of human pregnancies associated with obesity
ERTBB-073

 

Bambino – Developing novel in utero biomarkers for fetal hypoxia and perinatal brain injury – a proof of concept study
ERTBB-074

 

Expression of HRPE773 (ZG16B) in placenta, fetal membranes and uterine tissues in late pregnancy and at parturition
ERTBB-075

 

Studies on isolated tissues to investigate new medicines
ERTBB-076

 

Pilot study of a comparison of DNA methylation of cord blood samples from babies born to mothers with maternal diabetes during pregnancy compared with controls. 
ERTBB-077

 

Samples to CRO for preliminary study no pre-eclampsia markers
ERTBB-078

 

Efficacy of Metformin in pregnant obese women – a randomised controlled trial – EMPOWaR
ERTBB-079

 

Does genotype predict variability in HPA axis responses to pregnancy?
ERTBB-080

 

Evaluation of a therapeutic antibody against the FDA panel of normal tissues
ERTBB-081

 

Collection of umbilical cord
ERTBB-082
 
Characterising glucocorticoid transport across the placenta
ERTBB-083

 

iNKT cells as drivers for preterm labour
ERTBB-084

 

Steroid regulation of human myometrial contractions-the role of androgens
ERTBB-085

 

Does Chlamydia trachomatis have a causative role in miscarriage?
ERTBB-086
 
The role of the host defence peptide cathelicidin (LL37) in infection induced preterm labour
ERTBB-087
 
Imagin’: investigating associations between mother’s wellbeing in pregnancy and fetal brain size
ERTBB-088
 
Blood regeneration: de novo development of human haematopoietic stem cells
ERTBB-089

 

Does co-administration of glibenclamide and metformin lead to an accumulation of one or both drugs in the fetal circulation
ERTBB-090

 

Cortisol metabolism in the dual perfused human placenta
ERTBB-091

 

Metabolomics
ERTBB-092

 

Cervicovaginal secretion – predictors of preterm delivery
ERTBB-093
 
Pilot Study: assessment of the utility and acceptability of amniotic fluid erythropoietin levels in late pregnancy for women with type 1 diabetes
ERTBB-094
 
Investigation into the effects of labour and/or mode of delivery on DNA methylation in cord blood, placenta and cord tissue of newborns at term
ERTBB-095

 

Investigation of the biology of the giant panda reproductive cycle and pregnancy – request for (human) control samples
ERTBB-096
 
Investigation of the potential of Wharton’s jelly as a source of mesenchyme stromal cells
ERTBB-097

 

Long-term cold storage of biological samples – stability at different temperatures
ERTBB-098
 
Prematurity and programming: the role of telomere length
ERTBB-099
 
Transfer of cervix samples to be curated by ERTBB
ERTBB-100
 
‘CONCEPTT’ trial – Continuous glucose monitoring in women with type 1 diabetes in pregnancy trial
ERTBB-101
 
Design and clinical validation of a rapid, multiple pathogen test for use in puerperal sepsis screening
ERTBB-102

 

Lipidomics analysis during pregnancy
ERTBB-103

 

Maternal cortisol and the development origins of cardiometabolic disease
ERTBB-104