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Entorhinal circuit mechanisms for estimation of location

Neurons in the medial entorhinal cortex (MEC) generate estimates of location that are critical for navigation and for episodic memory.

While spatial coding by neurons in the MEC has been well described, the underlying neural mechanisms are not well understood. This project will address circuit mechanisms by which the MEC encodes location. Experimental approaches used will include application of genetic and molecular tools for manipulation of neural circuits and micro-endoscopy systems for imaging neural activity in freely moving animals. A number of potential research directions are available and it is expected that the successful applicant will play a role in determining the specific focus.

Primary supervisor

Prof Matthew Nolan

Nolan lab homepage

+44 (0)131 650 9874

Matt.Nolan@ed.ac.uk