Tom Misteli, National Cancer Institute, Bethesda, Maryland, USA
22nd August 2017 at 12:00pm [Download iCalendar / .ics file]
The genome is one of the major physical entities in the eukaryotic cell and is spatially and temporally highly organized. High-throughput imaging approaches are emerging as powerful tools to elucidate the cell biological properties of genomes and to link genome architecture to function at a single-cell level. Deep Imaging methods are based on the development of high-capacity, high-precision automated microscopes which allow acquisition of large imaging datasets and the implementation of computational image analysis and data mining methods to quantitatively capture morphological phenotypes. Deep Imaging enables new experimental strategies for the study of the genome including visualization and analysis of rare events such as chromosome breaks and translocations, use of large-scale imaging-based screens to probe molecular mechanisms of genome organization and function in an unbiased fashion, and they allow mapping of the genome in 3D space. These approaches are powerful tools to probe the cell biology of genomes and provide novel insights into genome architecture and function.
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