Vincent Gèli, CRCM, Marseilles, France
24th May 2017 at 12:00pm [Download iCalendar / .ics file]
The family of histone H3 lysine 4 (H3K4) methylases is highly conserved from yeast to human. They share a canonical organization in which the catalytic subunit acts as a docking platform for multiple subunits that regulate the enzymatic activity. Set1 complex (Set1C or COMPASS) mediated H3K4 methylation is one of the most prominent histone modifications that mark active transcription. In budding yeast, Set1C and H3K4 methylation have not only been involved in transcription but in multiple processes such as chromosome segregation, DNA replication, and meiotic recombination. Recent reports led to the concept that Set1C subunits, in addition to regulating H3K4 methylation, may be directly involved in some of these biological functions by recruiting specific protein partners. However, the mechanisms by which the Set1C protein interaction network promotes these processes remain poorly understood. In this talk, we will discuss these many faces of the Set1 complex.
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