Professor Zuzana Storchova - Max Planck Institute of Biochemistry, Munich
20th March 2017 at 12:00pm [Download iCalendar / .ics file]
Faithful duplication of chromosomes and their equal segregation into daughter cells is essential for survival of any organism on earth. Errors during chromosome segregation lead to chromosome gains and losses – the resulting daughter cells contain abnormal numbers of chromosomes, they become aneuploid. Aneuploidy is the major cause of spontaneous miscarriages. Moreover, more than 80 % of malignant tumors contain cells with aneuploid karyotype.
We have developed a model system of defined aneuploidies in human cells. In this lecture I will review our results that provide new insights about how abnormal chromosome numbers affect eukaryotic cells and how these changes may contribute to tumorigenesis.
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