Biological Sciences

Events and seminars

Monday Seminar Series - "The consequences of aneuploidy: From Down’s syndrome to cancer"

Professor Zuzana Storchova - Max Planck Institute of Biochemistry, Munich

20th March 2017 at 12:00pm [Download iCalendar / .ics file]

Daniel Rutherford, G.27, LT1

Faithful duplication of chromosomes and their equal segregation into daughter cells is essential for survival of any organism on earth. Errors during chromosome segregation lead to chromosome gains and losses – the resulting daughter cells contain abnormal numbers of chromosomes, they become aneuploid. Aneuploidy is the major cause of spontaneous miscarriages. Moreover, more than 80 % of malignant tumors contain cells with aneuploid karyotype. 

 

We have developed a model system of defined aneuploidies in human cells. In this lecture I will review our results that provide new insights about how abnormal chromosome numbers affect eukaryotic cells and how these changes may contribute to tumorigenesis.

Host Adele Marston

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