WT PhD Programme Seminar - Epigenetic memory over geological timescales
Hiten Madhani, Department of Biochemistry and Biophysics, UCSF, USA
3rd May 2017 at 12:00pm [Download iCalendar / .ics file]
Daniel Rutherford, G.27, LT1
This seminar will describe a DNA methylation system in the yeast Cryptococcus neoformans that displays strong functional similarities to the mammalian Dnmt1-dependent maintenance methylation system. Results demonstrating that the yeast system operates in a "maintenance-only" fashion will be presented. These findings raise the question of when methylation was initially established. Additional results will be described that shows that DNA methylation was established in an ancestor species that lived 50-150 million years ago by a de novo methylase whose gene was subsequently lost from the genome.
Host Robin Allshire
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